Title of article
On the mechanism of action of GTP-transforming enzymes
Author/Authors
Mark J. Dufton، نويسنده , , Colin L. Gibson، نويسنده , , Andrew R. Pitt، نويسنده , , Salah Athmani، نويسنده , , Colin J. Suckling، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
779
To page
784
Abstract
Mechanisms for the ring conversion of GTP into cofactor precursors by GTP cyclohydrolases and molybdopterin synthase are proposed and discussed in the context of the crystal structure of the GTP cyclohydrolase I - 2′-deoxy-GTP complex. The mechanisms suggest that common features of acid-base catalysis may underly the reactions catalysed in all three cases.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788652
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