Title of article
Synthesis and biological activities of truncated acridone: Structure-activity relationship studies of cytotoxic 5-hydroxy-4-quinolone
Author/Authors
Moon Woo Chun and، نويسنده , , Kay Kim Olmstead، نويسنده , , Yong Suck Choi، نويسنده , , Chong-Ock Lee، نويسنده , , Chong-Kyo Lee، نويسنده , , Joong Hyup Kim، نويسنده , , Jeewoo Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
789
To page
792
Abstract
A series of 5-hydroxy-4-quinolone (3) and 5-methoxy-4-quinolone (4) derivatives were synthesized as truncated acridone analogues and evaluated for antitumor and antiherpes activities. Among them 5-hydroxy-8-methoxy-quinolone showed potent antitumor activity (IC50 = 17.7 μM for HL60) which was greater than that of acronycine.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788653
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