Author/Authors :
Dane M. Springer، نويسنده , , Bing-Yu Luh، نويسنده , , Stan V. DʹAndrea، نويسنده , , Joanne J. Bronson، نويسنده , , Muzammil M. Mansuri، نويسنده , , James R. Burke، نويسنده , , Kurt R. Gregor، نويسنده , , Paul L. Stanley، نويسنده , , Kenneth M. Tramposch، نويسنده ,
Abstract :
Ten diacids were synthesized via a simple regio- and stereoselective aldol reaction. All of these compounds were good to excellent inhibitors of 14 kDa human platelet PLA2, and many of these derivatives displayed activity in a phorbol-ester induced mouse ear edema assay. One of the new compounds reported here was selected for further development as a potential antipsoriasis agent.
