Author/Authors :
George R. Pettit، نويسنده , , Jun-ping Xu، نويسنده , , Michael D. Williams، نويسنده , , Fiona Hogan، نويسنده , , Jean M. Schmidt، نويسنده , , Ronald L. Cerny، نويسنده ,
Abstract :
Bioassay-guided separation of cancer cell growth inhibitory fractions derived from the sea hare Dolabella auricularia obtained in Papua New Guinea led to isolation (1.51 × 10−7% yield) of the new thiazole-containing peptide, dolastatin 18 (4). Structural determination was completed by employmentment of results from high-field (500 MHz) 2-D NMR experiments and tandem MS/MS mass spectral sequence analyses. Dolastatin 18 (4) was found to inhibit a selection of cancer cell lines among which GI50 0.39 μg/mL was found for the nonsmall cell lung cancer NCI-H460.
