Title of article
Synthesis and evaluation of dual action cephalosporins as elastase inhibitors
Author/Authors
Grigory Veinberg، نويسنده , , Irina Shestakova، نويسنده , , Larisa Petrulanis، نويسنده , , Nora Grigan، نويسنده , , Dan Musel، نويسنده , , Dairis Zeile، نويسنده , , Iveta Kanepe، نويسنده , , Ilona Domrachova، نويسنده , , Ivars Kalvinsh، نويسنده , , Andris Strakovs، نويسنده , , Edmunds Lukevics، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
843
To page
846
Abstract
tert-Butyl 7α-chloro and 7α-methoxycephalosporanate 1,1-dioxides containing Aspirin and Diclofenac in their 3-acyloxymethyl moiety were synthesized. These dual action cephalosporins have been found to be potent elastase inhibitors and stimulators of NO biosynthesis in macrophages.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788663
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