Author/Authors :
Andrew D. Baxter، نويسنده , , John Bird، نويسنده , , Ranjev Bhogal، نويسنده , , Tracy Massil، نويسنده , , Kevin J. Minton، نويسنده , , John Montana، نويسنده , , David A. Owen، نويسنده ,
Abstract :
The preparation of a novel series of matrix metalloproteinase inhibitors is described, based on the use of a mercaptoacyl zinc binding moiety. The compounds have been tested in a model of rheumatoid arthritis and show good oral activity.
