Title of article
Amide bond surrogates: A study in thiophenesulfonamide based endothelin receptor antagonists
Author/Authors
C. B. Raju ، نويسنده , , Ilya Okun، نويسنده , , Fiona Stavros، نويسنده , , Ming Fai Chan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
939
To page
944
Abstract
The potential proteolytic instability of the amide bond present in some ETA selective thiophenesulfonamide endothelin antagonists exemplified by TBC-10708 led us to investigate the replacement of this moiety with stable amide bond surrogates such as a trans double bond and an ethylene spacer. The effect of these replacements on the binding affinity is described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788682
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