Bioactivatable derivatives of 8-substituted cAMP-analogues
Author/Authors :
Jens Kruppa، نويسنده , , Stephen Keely، نويسنده , , Frank Schwede، نويسنده , , Carsten Schultz، نويسنده , , Kim E. Barrett، نويسنده , , Bernd Jastorff، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Pages :
4
From page :
945
To page :
948
Abstract :
Four 8-substituted derivatives of cAMP were converted into their membrane-permeant acetoxymethyl esters (AM-esters). The activity of these bioactivatable compounds to induce chloride secretion of T84 cells was up to 100-fold increased compared to the non-modified cAMP derivatives.
