Title of article
Synthesis, evaluation and Tc-99m complexation of a hydrazinonicotinyl conjugate of a GP IIb/IIIa antagonist cyclic peptide for the detection of deep vein thrombosis
Author/Authors
Milind Rajopadhye، نويسنده , , Thomas D. Harris، نويسنده , , Karmine Yu، نويسنده , , Danuta Glowacka، نويسنده , , Paul R. Damphousse، نويسنده , , John A. Barrett، نويسنده , , Stuart J. Heminway، نويسنده , , D. Scott Edwards، نويسنده , , Timothy R. Carroll، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
955
To page
960
Abstract
A cyclic peptide GP IIb/IIIa receptor antagonist containing the N-Me-Arg-Gly-Asp motif has been derivatized with the technetium chelating hydrazinonicotinyl group (Hynic). The Hynic derivative, and the Tc-99 diazenido complex, retain the high receptor affinity of the parent peptide. The Tc-99m complex shows high thrombus uptake, and rapid clearance of background, producing excellent images in under 1 h.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788685
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