Synthesis and inhibitory effect of a sialyl lewis X-acrylamide homopolymer at preventing cell adhesion

A novel glycopolymer, a homopolymer of conjugated SLeX-acrylamide, was synthesized and evaluated for its inhibitory activity against E-selectin mediated cell adhesion both in vitro and in vivo. The homopolymer showed approximately 10-fold higher activity per SLeX unit than the corresponding SLeX-acrylamide monomer in vitro and was significantly more effective in an LTA-induced murine pleurisy model.