Title of article
Synthesis and inhibitory effects of bivalent sialyl lewis X analogs at preventing cell adhesion
Author/Authors
Hiroshi Miyauchi، نويسنده , , Masatoshi Yuri، نويسنده , , Masashi Tanaka، نويسنده , , Nobuko Kawamura، نويسنده , , Masaji Hayashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
989
To page
992
Abstract
Several sialyl Lewis X (SLeX) dimers attached to symmetric linkers, 1,3-di(ω-hydroxyalkyl)-benzene, 1,3-di(ω-hydroxyalkoxy)benzene, and 1,3-di(ω-hydroxyalkoxy)cyclohexane, were synthesized and evaluated for their inhibitory activity against adhesion of HL-60 cells to recombinant soluble E-selectin. The SLeX dimers showed 4 to 6-fold higher inhibitory activity than the corresponding monomers.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788692
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