Author/Authors :
Roland E. Dolle، نويسنده , , Denton Hoyer، نويسنده , , James M. Rinker، نويسنده , , Tina Morgan Ross، نويسنده , , Stanley J. Schmidt، نويسنده , , Carla T. Helaszek، نويسنده , , Mark A. Ator، نويسنده ,
Abstract :
The 3-chloro-4-carboxamido-6-arylpyridazines are a novel class of interleukin-1β converting enzyme (ICE) inhibitor. These agents are irreversible inhibitors with pyridazine 23 possessing a kobs/[I] = 355 M−1s−1. A structure-activity relationship for this non-peptide class of compounds and the putative mechanism for irreversible inactivation are described.
