Author/Authors :
John H. Tatlock، نويسنده , , M. Angelica Linton، نويسنده , , Xinjun J. Hou، نويسنده , , Charles R. Kissinger، نويسنده , , Laura A. Pelletier، نويسنده , , Richard E. Showalter، نويسنده , , Anna Tempczyk-Russell، نويسنده , , J. Ernest Villafranca، نويسنده ,
Abstract :
The design, synthesis, and evaluation of small molecule, in vitro, inhibitors of human calcineurin is described. These ligands were derived from the known nonspecific phosphatase inhibitor endothall, and were modified to enhance binding and selectivity toward calcineurin using protein crystal structure information.
