Automated solid-phase organic synthesis in micro-plate wells. Synthesis of N-(alkoxy-acyl)amino alcohols

The technique of concurrent solid-phase organic synthesis in 96-deep-well micro-titer plates is outlined and documented with the synthesis of N-(alkoxy-acyl)amino alcohols. Typically resin beads are separated from solvent using filtration approach that complicates automation. Instead we describe a method employing settling of resin, followed by aspiration of supernatant.