Author/Authors :
Laurence E. Burgess، نويسنده , , Kevin Koch، نويسنده , , Kelvin Cooper، نويسنده , , Michael S. Biggers، نويسنده , , Mukesh Ramchandani، نويسنده , , Jacqueline H. Smitrovich، نويسنده , , Eric J. Gilbert، نويسنده , , Matthew J. Bruns، نويسنده , , Robert J. Mather، نويسنده , , Carol B. Donovan، نويسنده , , Douglas C. Hanson، نويسنده ,
Abstract :
UK-78,282 was identified in a human T cell 86Rb efflux high-throughput screen of our compound libraries. This compound was found to be a potent and selective blocker of human T cell voltage-gated K+ channels and to inhibit T cell activation. The SAR around UK-78,282 and a general pharmacophore hypothesis are presented in this communication.
