Title of article
The SAR of UK-78,282: A novel blocker of human T cell Kv1.3 potassium channels
Author/Authors
Laurence E. Burgess، نويسنده , , Kevin Koch، نويسنده , , Kelvin Cooper، نويسنده , , Michael S. Biggers، نويسنده , , Mukesh Ramchandani، نويسنده , , Jacqueline H. Smitrovich، نويسنده , , Eric J. Gilbert، نويسنده , , Matthew J. Bruns، نويسنده , , Robert J. Mather، نويسنده , , Carol B. Donovan، نويسنده , , Douglas C. Hanson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1047
To page
1052
Abstract
UK-78,282 was identified in a human T cell 86Rb efflux high-throughput screen of our compound libraries. This compound was found to be a potent and selective blocker of human T cell voltage-gated K+ channels and to inhibit T cell activation. The SAR around UK-78,282 and a general pharmacophore hypothesis are presented in this communication.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788705
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