Author/Authors :
Amy Pyluck، نويسنده , , Ruiyong Yuan، نويسنده , , Edward Galligan Jr.، نويسنده , , Paul Primakoff، نويسنده , , Diana G. Myles، نويسنده , , Nicole S. Sampson، نويسنده ,
Abstract :
Cyclic and linear peptides containing the conserved ECD sequence from the disintegrin domain of the β-subunit of fertilin were synthesized and tested as inhibitors of sperm-egg fusion in in vitro mouse fertilization assays. At 500 μM concentrations, reduced ECD peptides inhibited fertilization, whereas oxidized dimers did not. Control peptides suggest that more than three amino acids of the disintegrin domain are recognized by its receptor.
