Author/Authors :
F. Schmidt، نويسنده , , Florent J. C.، نويسنده , , C. Monneret، نويسنده , , R. Straub، نويسنده , , J. Czech، نويسنده , , M. Gerken، نويسنده , , K. Bosslet، نويسنده ,
Abstract :
A prodrug consisting of a β-D-glucuronic acid linked to a self-immolative spacer (a N-(ortho-hydroxyphenyl)-N-methylcarbamate) and a phenolic nitrogen mustard was synthesised. As this prodrug was easily cleaved by a β-glucuronidase enzyme and displayed low cytotoxicity, it must be considered as appropriate for an ADEPT approach.
