Title of article :
Synthesis, characterization, interaction with DNA, and antitumor activity of a cis-Dichloroplatinum(II) complex linked to an intercalator via one methylene chain
Author/Authors :
Yuji Mikata، نويسنده , , Kaoru Mogami، نويسنده , , Masako Kato، نويسنده , , Ichiro Okura، نويسنده , , Shigenobu Yano، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Abstract :
A cisplatin-type complex tethered to acridine intercalator via one methylene chain has been synthesized. Its structure was elucidated by X-ray crystallography. A permeability into cell, interaction with calf thymus DNA (ct-DNA), and antitumor activity against HeLa and P388 cells were studied.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
