Title of article
Rollimembrin, a novel acetogenin inhibitor of mammalian mitochondrial complex I
Author/Authors
M. Carmen Gonzalez Roa، نويسنده , , JoséR. Tormo، نويسنده , , Almudena Bermejo، نويسنده , , M. Carmen Zafra-polo، نويسنده , , Ernesto Estornell، نويسنده , , Diego Cortes، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1113
To page
1118
Abstract
Rollimembrin (3), is a new adjacent bis-tetrahydrofuranic acetogenin with a scarce relative configuration, threo/cis/threo/cis/erythro, isolated from Rollinia membranacea seeds. The mechanism of cytotoxic activity, determined by NADH-oxidase experiments, establish that rollimembrin (3) is the most potent inhibitor of mammalian mitochondrial complex I.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788718
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