Novel polyamide based nucleic acid analogs-synthesis of oligomers and RNA-binding properties

The synthesis of novel polyamide based nucleic acid analogs incorporating monomer units of type I – III has been accomplished using solid-phase strategies based on Nδ-Fmoc protected building blocks. An oligomer composed of monomer units I exhibited weak, but sequence-specific RNA binding. Improved RNA-binding affinity was observed for analogs incorporating building blocks of type III with 2-(R) stereochemistry, but not in the case of the 2-(S) isomers.