Title of article
Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists
Author/Authors
Dawei Ma، نويسنده , , Hongqi Tian، نويسنده , , Hongbin Sun، نويسنده , , Alan P. Kozikowshi، نويسنده , , Sergey Pshenichkin، نويسنده , , Jarda T. Wroblewski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
1195
To page
1198
Abstract
The synthesis of two rigidified phenylglycine analogues is disclosed. The cyclic analogue 1 of (R,S)-α-methyl-4-phosphonophenylglycine (MPPG) is shown to be a particularly interesting pharmacological tool, for it is a group II selective mGluR antagonist that possesses an inverse agonist-like-action.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788735
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