Author/Authors :
Mark Froimowitz، نويسنده , , Howard M. Deutsh، نويسنده , , Quing Shi، نويسنده , , Kuo-Ming Wu، نويسنده , , Robert Glaser، نويسنده , , Itay Adin، نويسنده , , Clifford George، نويسنده , , Margaret M. Schweri، نويسنده ,
Abstract :
N-methyl derivatives of methylphenidate and four analogs were synthesized and assayed for affinity at the dopamine transporter. The binding affinities of the N-methyl compounds were consistently lower by a factor ranging from 4 to 30 as compared with the corresponding secondary amine. This is consistent with the predictions of a pharmacophore model of compounds that bind to the dopamine transporter.
