PIPERIDINE CARBOXYLIC ACID DERIVATIVES AS SIALYL LEWIS X MIMETICS

Four piperidine carboxylic acid derivatives designed as mimetics of the sialyl Lewis X determinant were synthesized. Their inhibitory potency for selectin mediated cell adhesion was evaluated in cell culture assays, in vivo and in a reperfusion model. Compound 7 showed strong inhibition of leukocyte adhesion in rats and a powerful decrease of the incidence of arrhythmias in a reperfusion model in isolated rabbit hearts. © 1997 Elsevier Science Ltd.