Title of article
MALONIC ACID DERIVATIVES AS SIALYL LEWIS X MIMETICS
Author/Authors
Alexander Toepfer، نويسنده , , Gerhard Kretzschmar، نويسنده , , Silke Schuth، نويسنده , , Michael Sonnentag، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1317
To page
1322
Abstract
Malonic acid derivatives designed as mimetics of the sialyl Lewis X determinant were synthesized. Their inhibitory potency for selectin mediated cell adhesion was evaluated in cell culture assays and in vivo. The receptor binding affinity for E- and P-selectins of simple mimetics was found to be comparable to the potency of the tetrasaccharide sialyl Lewis X. © 1997 Elsevier Science Ltd.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788761
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