Title of article
PYRIDONE-BASED PEPTIDOMIMETIC INHIBITORS OF INTERLEUKIN-1β-CONVERTING ENZYME (ICE)
Author/Authors
Graeme Semple، نويسنده , , Doreen M. Ashworth، نويسنده , , Graham R. Baker، نويسنده , , Andrzej R. Batt، نويسنده , , Andrew J. Baxter، نويسنده , , David W. M. Benzies، نويسنده , , Lucy H. Elliot، نويسنده , , D. Michael Evans، نويسنده , , Richard J. Franklin، نويسنده , , Peter Hudson، نويسنده , , Paul D. Jenkins، نويسنده , , Gary R. Pitt، نويسنده , , David P. Rooker، نويسنده , , Andrew Sheppard، نويسنده , , Michael Szelke، نويسنده , , Satoshi Yamamoto، نويسنده , , Yasuo Isomura، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1337
To page
1342
Abstract
New potent, reversible inhibitors of recombinant human Interleukin-1β-converting enzyme (ICE, caspase-1) with significantly reduced peptide character are described. The compounds were designed by incorporation of pyridone and pyrimidone heterocyclic replacements for the P2-P3 amino acids of the native substrate and were optimised by manipulation of peripheral alkyl and aryl substituents. © 1997 Elsevier Science Ltd.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788765
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