Title of article
Functionalized aliphatic P2/P2′ analogs of HIV-1 protease inhibitor DMP323
Author/Authors
Joanne M. Smallheer، نويسنده , , Robert J. McHugh، نويسنده , , Chong-Hwan Chang، نويسنده , , Robert F. Kaltenbach III، نويسنده , , Tabitha V. Worley، نويسنده , , Ronald M. Klabe، نويسنده , , Lee T. Bacheler، نويسنده , , Marlene M. Rayner، نويسنده , , Susan Erickson-Viitanen، نويسنده , , Steven P. Seitz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1365
To page
1370
Abstract
A series of analogs of HIV protease inhibitor DMP323 containing functionalized aliphatic P2/P2′ groups was prepared and evaluated for HIV protease inhibition and antiviral activity in a cell-based assay. Asymmetric compounds with a 5-hydroxypentyl substituent at P2 and a benzylic substituent at P2′ showed increased potency over the corresponding symmetrically substituted analogs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788771
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