Author/Authors :
Joanne M. Smallheer، نويسنده , , Robert J. McHugh، نويسنده , , Chong-Hwan Chang، نويسنده , , Robert F. Kaltenbach III، نويسنده , , Tabitha V. Worley، نويسنده , , Ronald M. Klabe، نويسنده , , Lee T. Bacheler، نويسنده , , Marlene M. Rayner، نويسنده , , Susan Erickson-Viitanen، نويسنده , , Steven P. Seitz، نويسنده ,
Abstract :
A series of analogs of HIV protease inhibitor DMP323 containing functionalized aliphatic P2/P2′ groups was prepared and evaluated for HIV protease inhibition and antiviral activity in a cell-based assay. Asymmetric compounds with a 5-hydroxypentyl substituent at P2 and a benzylic substituent at P2′ showed increased potency over the corresponding symmetrically substituted analogs.
