Title of article
Solid-phase synthesis of a selective αvβ3 integrin antagonist library
Author/Authors
Jeffrey W. Corbett، نويسنده , , Nilsa R. Graciani، نويسنده , , Shaker A. Mousa، نويسنده , , William F. DeGrado، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1371
To page
1376
Abstract
Solid-phase synthesis was used to generate a focused RGD peptide mimetic library in an effort to identify potent and selective αvβ3 integrin antagonists. Increased activity was observed for compounds possessing a urea linkage to piperazine, with the most active compound (28) exhibiting an IC50 = 1.1 nM in an αvβ3 ELISA assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788772
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