Author/Authors :
Stephen Neidle، نويسنده , , L. R. Kelland، نويسنده , , J. O. Trent، نويسنده , , I. J. Simpson، نويسنده , , D. W. Boykin، نويسنده , , A. Kumar، نويسنده , , W. D. Wilson، نويسنده ,
Abstract :
A series of alkyl derivatives of bis(phenylamidinium)furan are shown to have cytotoxic activity in several human tumour cell lines. Xray crystallographic studies have previously shown that these compounds bind in the AT region of the DNA minor groove. It is suggested that activity is linked to this AT groove binding.
