Title of article
Studies on β-lactam antibiotics. Synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs
Author/Authors
Hidenori Azami، نويسنده , , J. DAVID BARRETT، نويسنده , , Akira Tanaka، نويسنده , , Hiroshi Sasaki، نويسنده , , Keiji Matsuda، نويسنده , , Minoru Sakurai، نويسنده , , Yoshimi Matsumoto، نويسنده , , Shuichi Tawara، نويسنده , , Toshiyuki Chiba، نويسنده , , Kazuo Sakane، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1409
To page
1414
Abstract
The synthesis and biological activity of the novel series of 1β-methylcarbapenems 1 are described. Most compounds displayed extremely potent antibacterial activity and high renal DHP-I stability. The best compound in this series, FR21818 (1a) displayed excellent in vivo efficacy against an MRSA infection in mice.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788779
Link To Document