Title of article
The use of gaseous ammonia for the deprotection and cleavage steps during the solid-phase synthesis of oligonucleotides, and analogs
Author/Authors
Radhakrishnan P. Iyer، نويسنده , , Dong Yu، نويسنده , , Xian-Jin Xie، نويسنده , , Wen Zhou، نويسنده , , Sudhir Agrawal، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1443
To page
1448
Abstract
The use of NH3 gas under pressure offers an efficient alternative to hot aqueous ammonium hydroxide for the deprotection, and cleavage steps during the large-scale synthesis of oligonucleotides, and their analogs prepared using N-pent-4-enoyl (PNT) nucleoside phosphoramidites and H-phosphonates.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788786
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