Title of article
Synthesis and antirheumatic activity of novel tetrahydro-6-quinolineacetic acid derivatives
Author/Authors
Yasushi Kohno، نويسنده , , Katsuya Awano، نويسنده , , Mitsutomo Miyashita، نويسنده , , Takayoshi Ishizaki، نويسنده , , Kazuhiko Kuriyama، نويسنده , , Yasuhiko Sakoe، نويسنده , , Shinji Kudoh، نويسنده , , Koji Saito، نويسنده , , Eisuke Kojima، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1519
To page
1524
Abstract
A study of the structural optimization of tetrahydroquinoline-6-acetic acid and the development of a novel DMARD with prompt action are detailed. (S)-(+)-8-Chloro-1,2,3,4-tetrahydro-2-trifluoromethyl-6-quinolineacetic acid (IRA-378) exhibits the effect against both acute and chronic inflammations. It also has suppressive effects of bone destruction in adjuvant arthritis and Ca release from bones in vitro.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788802
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