Title of article
Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates
Author/Authors
Susan Y. Tamura، نويسنده , , J. Edward Semple، نويسنده , , John E. Reiner، نويسنده , , Erick A. Goldman، نويسنده , , Terence K. Brunck، نويسنده , , Marguerita S. Lim-Wilby، نويسنده , , Stephen H. Carpenter، نويسنده , , William E. Rote، نويسنده , , Gerard L. Oldeshulte، نويسنده , , Brigitte M. Richard، نويسنده , , Ruth F. Nutt، نويسنده , , William C. Ripka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1543
To page
1548
Abstract
Several potent and selective inhibitors of thrombin incorporating novel heterocyclic peptide surrogates in the P3-P2 position of peptidyl argininals have been discovered. Illustrated in this article are three classes of heterocycles: pyridones, uracils, and pyrimidinones. The synthesis and biological activities of these unique aromatic heterocyclic derivatives are reported herein.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788806
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