Author/Authors :
Yang-I Lin، نويسنده , , Panayota Bitha، نويسنده , , Subas M. Sakya، نويسنده , , Zhong Li، نويسنده , , Stanley A. Lang Jr.، نويسنده , , Youjun Yang، نويسنده , , Niraja Bhachech، نويسنده , , William J. Weiss، نويسنده , , Peter J. Petersen، نويسنده , , Nilda V. Jacobus، نويسنده , , Karen Bush and Osnat Herzberg، نويسنده , , Raymond T. Testa، نويسنده ,
Abstract :
Peptidic prodrugs of the five most active aminomethyl-THF 1β-methylcarbapenems were synthesized. Of these, only L-amino acid derivatives from 1a demonstrated an improved oral activity. These results indicate that the L-amino acid derivatives from 1a are orally absorbed most likely through the dipeptide and tripeptide transport mechanism.
