Title of article
Synthesis and structure-activity relationships of novel THF 1β-methylcarbapenems
Author/Authors
Yang-I Lin، نويسنده , , Panayota Bitha، نويسنده , , Subas M. Sakya، نويسنده , , Timothy W. Strohmeyer، نويسنده , , Zhong Li، نويسنده , , Ving J. Lee، نويسنده , , Stanley A. Lang Jr.، نويسنده , , Youjun Yang، نويسنده , , Niraja Bhachech، نويسنده , , William J. Weiss، نويسنده , , Peter J. Petersen، نويسنده , , Nilda V. Jacobus، نويسنده , , Karen Bush and Osnat Herzberg، نويسنده , , Raymond T. Testa، نويسنده , , Francis P. Tally، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1671
To page
1676
Abstract
A series of twelve highly active aminomethyl-THF 1β-methylcarbapenems 3a-1 were synthesized. Of these, carbapenems 3a-f demonstrated a spectrum of antimicrobial activity comparable to those of imipenem and meropenem with the exception of only moderate anti-pseudomonal activity. Most importantly, they demonstrated moderate intrinsic oral activity against an E. coli infection in mice.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788830
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