Author/Authors :
K?nai K?roly، نويسنده , , Erd S?ndor، نويسنده , , Sus?n Edit، نويسنده , , Fehér Mikl?s، نويسنده , , Sipos Judit، نويسنده , , Pod?nyi Benj?min، نويسنده , , Szappanos Andrea، نويسنده , , Hermecz Istv?n، نويسنده ,
Abstract :
A series of N-acyl derivatives of thioproline-pyrrolidine was prepared conventionally and evaluated in vitro against rat brain prolyl endopeptidase (PEP). It is argued on the basis of pharmacophore plots that an optimum chain length exists as a result of increased population of pharmacophore space and decreased solubility on increasing the alkyl chain length.
