Synthesis and characterization of polyaspartic acid-carbohydrate conjugates: Multivalent sialyl lewis

A protocol for the functionalization of polyaspartimide (PAI) with carbohydrates containing an amino funtion at the reducing end to give biodegradable neoglycoconjugates such as 4 is presented. Scope and limitation of the strategy with respect to the preparation of multivalent sialyl Lewisx5 are discussed.