Title of article
RES-701-1/endothelin-1 hybrid peptide having a potent binding activity for type B receptor
Author/Authors
Toshiyuki Suzawa، نويسنده , , Kenji Shibata، نويسنده , , Takeo Tanaka، نويسنده , , YUZURU MATSUDA، نويسنده , , Motoo Yamasaki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1715
To page
1720
Abstract
N-Terminal cyclic peptide of RES-701-1, an endothelin (ET) type B receptor selective antagonist, was chemically combined to C-terminal peptide of ET family. Among a series of the hybrid peptide synthesized, RES-701-1(1–10)/[A15]ET-1(12–21) hybrid peptide possessed both a potent binding activity with an IC50 value of 0.24nM and a selectivity for type B receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788839
Link To Document