Author/Authors :
Heather J. Finlay، نويسنده , , Tadashi Honda، نويسنده , , Gordon W. Gribble، نويسنده , , David Danielpour، نويسنده , , Nicole E. Benoit، نويسنده , , Nanjoo Suh، نويسنده , , Charlotte Williams، نويسنده , , Michael B. Sporn، نويسنده ,
Abstract :
Syntheses of eight novel A-ring cleaved oleanane and ursane analogs are described. These compounds were assessed for their ability to inhibit cell proliferation in NRP.152 prostate cells. Four A-ring cleaved derivatives showed significant activity; 5β-(1-methyl-2-ethyl)-10α-(3-aminopropyl)-des-A-urs-12-en-28-oic acid was the most active compound, (IC50, 0.3μM).
