Title of article
FKBP12-binding domain analogues of FK506 are potent, nonimmunosuppressive neurotrophic agents in vitro and promote recovery in a mouse model of parkinsonʹs disease
Author/Authors
G. S. Hamilton، نويسنده , , W. Huang، نويسنده , , M. A. Connolly، نويسنده , , D. T. Ross، نويسنده , , H. Guo، نويسنده , , H. L. Valentine، نويسنده , , P. D. Suzdak، نويسنده , , J. P. Steiner، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1785
To page
1790
Abstract
A series of simple N-(glyoxyl)pipecolate esters were synthesized as mimics of the FKBP12- binding domain portion of FK506. Compounds which were effective inhibitors of the prolyl isomerase activity of FKBP12 were extraordinarily potent neurotrophic agents in vitro, and were effective in a mouse model of Parkinsonʹs Disease. These results suggest that FKBP12 ligands have therapeutic utility in neurodegenerative diseases.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788853
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