Author/Authors :
G. S. Hamilton، نويسنده , , W. Huang، نويسنده , , M. A. Connolly، نويسنده , , D. T. Ross، نويسنده , , H. Guo، نويسنده , , H. L. Valentine، نويسنده , , P. D. Suzdak، نويسنده , , J. P. Steiner، نويسنده ,
Abstract :
A series of simple N-(glyoxyl)pipecolate esters were synthesized as mimics of the FKBP12- binding domain portion of FK506. Compounds which were effective inhibitors of the prolyl isomerase activity of FKBP12 were extraordinarily potent neurotrophic agents in vitro, and were effective in a mouse model of Parkinsonʹs Disease. These results suggest that FKBP12 ligands have therapeutic utility in neurodegenerative diseases.
