Title of article :
Molecular modeling of the interaction of trypanocide guanyl hydrazones with B-DNA
Author/Authors :
Osvaldo A. Santos-Filho، نويسنده , , J. Daniel Figueroa-Villar، نويسنده , , Martha T. Araujo، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Abstract :
Molecular modeling of the interaction of trypanocide aromatic guanyl hydrazones with B-DNA showed that the preferential sites for interaction are the DNA minor groove AT rich regions, with hydrogen bonding between the guanidine moiety of the drugs and the thymine O2, and the adenine N3. There is a correlation between the total interaction energy and ID50.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
