Title of article
Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems
Author/Authors
Yang-I Lin، نويسنده , , Panayota Bitha، نويسنده , , Zhong Li، نويسنده , , Subas M. Sakya، نويسنده , , Timothy W. Strohmeyer، نويسنده , , Stanley A. Lang Jr.، نويسنده , , Youjun Yang، نويسنده , , Niraja Bhachech، نويسنده , , William J. Weiss، نويسنده , , Peter J. Petersen، نويسنده , , Nilda V. Jacobus، نويسنده , , Karen Bush and Osnat Herzberg، نويسنده , , Raymond T. Testa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1811
To page
1816
Abstract
Mono and bis double ester prodrugs of aminomethyl THF 1β-methylcarbapenems 1 were synthesized. Mono double ester derivatives (2, 4 and 7) did not demonstrate significantly improved oral activity due to the presence of the charged species. However, bis double ester derivatives (3 and 5) demonstrated enhanced oral activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788857
Link To Document