Author/Authors :
Matthew A. Williams، نويسنده , , Willard Lew، نويسنده , , Dirk B. Mendel، نويسنده , , Chun Y. Tai، نويسنده , , Paul A. Escarpe، نويسنده , , W. Graeme Laver، نويسنده , , Raymond C. Stevens، نويسنده , , Choung U. Kim، نويسنده ,
Abstract :
The structure-activity relationships (SAR) for a new class of potent inhibitors (1) of influenza neuraminidase are described. Systematic modifications of substituents at the C-3, C-4, and C-5 positions of the carbocyclic ring were performed to establish fundamental SAR to assist in the design of potent inhibitors with activity against both of influenza A and B viruses.
