Title of article :
1,4-Diaryl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acids as endothelin receptor antagonists
Author/Authors :
Werner W. K. R. Mederski، نويسنده , , Mathias Osswald، نويسنده , , Dieter Dorsch، نويسنده , , Maria Christadler، نويسنده , , Claus-Jochen Schmitges، نويسنده , , Claudia Wilm، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Abstract :
The discovery, synthesis and structure-activity relationships of a series of novel 1,4-diaryl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acids as non-selective endothelin ETA / ETB receptor antagonists are described. The most potent inhibitor 3m displayed an IC50 of 260 nM and 200 nM for ETA and ETB receptors, respectively.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
