Author/Authors :
Marino Artico، نويسنده , , Roberto Di Santo، نويسنده , , Roberta Costi، نويسنده , , Silvio Massa، نويسنده , , Franca Scintu، نويسنده , , Anna Giulia Loi، نويسنده , , Antonella De Montis، نويسنده , , Paolo La Colla، نويسنده ,
Abstract :
Various 1-arylsulfonyl-3-(α-hydroxybenzyl)-1H-pyrroles were prepared by Friedel-Crafts reaction of 1-arylsulfonyl-1H-pyrroles with aroylchlorides in the presence of aluminum trichloride, followed by reduction of the ketones to the required carbinols. Title compounds were identified as a novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors characterized by the presence of a diarylcarbinol moiety, a chemical feature that strictly correlates with the anti-HIV-1 activity.
