• Title of article

    Synthesis of N-desmethyl PNQX: elaboration into an immunogenic conjugate and a radioiodinated ligand; radioimmunoassay for the AMPA/NMDA antagonist, PNQX

  • Author/Authors

    Christopher F. Bigge، نويسنده , , C. Stephen Yi، نويسنده , , Gerald D. Nordblom، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1997
  • Pages
    6
  • From page
    1979
  • To page
    1984
  • Abstract
    A nine-step synthesis of N-desmethyl PNQX 5 and its subsequent elaboration into analogs, a porcine thyroglobulin immunogenic conjugate 8, and a radioiodinated analyte 10 are described. These compounds were used for the development of a specific radioimmunoassay for PNQX, a potent neuroprotective agent with mixed AMPA/NMDA glycine site antagonist activity.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    1997
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    788890

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=788890