Author/Authors :
Michel Souchet، نويسنده , , Marie-Claire Forest، نويسنده , , Ute Gerhard، نويسنده , , Richard J. Smith، نويسنده , , Brigitte Cheval، نويسنده , , Sabine Rouanet، نويسنده , , Jean-François Faivré، نويسنده , , Antoine Bril، نويسنده ,
Abstract :
2-Azabicyclo[2.2.2]octane derivatives have been used as conformationally constrained structure of BRL-32872, in order to investigate the effect of molecular flexibility towards class III and class IV antiarrhythmic properties. Extensive NMR studies allowed the determination of the configuration at C5. Stereoisomerism induces variability of biological profile.
