Title of article
Synthesis of conformationally constrained analogues of BRL-32872. Determination of stereochemistry and related pharmacological properties
Author/Authors
Michel Souchet، نويسنده , , Marie-Claire Forest، نويسنده , , Ute Gerhard، نويسنده , , Richard J. Smith، نويسنده , , Brigitte Cheval، نويسنده , , Sabine Rouanet، نويسنده , , Jean-François Faivré، نويسنده , , Antoine Bril، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
1989
To page
1994
Abstract
2-Azabicyclo[2.2.2]octane derivatives have been used as conformationally constrained structure of BRL-32872, in order to investigate the effect of molecular flexibility towards class III and class IV antiarrhythmic properties. Extensive NMR studies allowed the determination of the configuration at C5. Stereoisomerism induces variability of biological profile.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788892
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