Author/Authors :
Izzy Boyfield، نويسنده , , Martyn C. Coldwell، نويسنده , , Michael S. Hadley، نويسنده , , Christopher N. Johnson، نويسنده , , Graham J. Riley، نويسنده , , Emma E. Scott، نويسنده , , Rachel Stacey، نويسنده , , Geoffrey Stemp، نويسنده , , Kevin M. Thewlis، نويسنده ,
Abstract :
A novel series of N-[4-(4-Phenylbenzoylamino)butyl]-1,2,3,4-tetrahydro-2-naphthylamines with high affinity and selectivity for the dopamine D3 receptor has been prepared. The 5-cyclopropylmethyloxy 3j, methanesulfonyloxy 3k and trifluoromethanesulfonyloxy 3l derivatives represent some of the highest affinity (pKiʹs 8.6–8.9) and most selective (200–320-fold) dopamine D3 receptor antagonists reported to date.
