Title of article
SAR study of the indole moiety of CI-988, a potent and selective CCK-B antagonist
Author/Authors
Corinne E. Augelli-Szafran، نويسنده , , Terri S. Purchase، نويسنده , , Bruce D. Roth، نويسنده , , Bradley Tait، نويسنده , , Bharat K. Trivedi، نويسنده , , Michael Wilson، نويسنده , , Nirmala Suman-Chauhan، نويسنده , , Louise Webdale، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2009
To page
2014
Abstract
Due to the interesting pharmacological activity observed for CI-988, a potent and selective CCK-B receptor antagonist, we have continued to study the SAR of this antagonist. This particular study examines the importance of the indole moiety for binding affinity. The synthesis and receptor binding affinity for analogs containing functionalized indole derivatives and replacing the indole with various heterocycles are reported.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788896
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