Author/Authors :
Corinne E. Augelli-Szafran، نويسنده , , Terri S. Purchase، نويسنده , , Bruce D. Roth، نويسنده , , Bradley Tait، نويسنده , , Bharat K. Trivedi، نويسنده , , Michael Wilson، نويسنده , , Nirmala Suman-Chauhan، نويسنده , , Louise Webdale، نويسنده ,
Abstract :
Due to the interesting pharmacological activity observed for CI-988, a potent and selective CCK-B receptor antagonist, we have continued to study the SAR of this antagonist. This particular study examines the importance of the indole moiety for binding affinity. The synthesis and receptor binding affinity for analogs containing functionalized indole derivatives and replacing the indole with various heterocycles are reported.
