Title of article
Synthesis and phosphatase inhibitory activity of analogs of sulfircin
Author/Authors
Regina E. Cebula، نويسنده , , Jill L. Blanchard، نويسنده , , Michael D. Boisclair، نويسنده , , Kollol Pal، نويسنده , , Nicholas J. Bockovich، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
2015
To page
2020
Abstract
Analogs of sulfircin (1) were synthesized and tested for inhibitory activity against a panel of phosphatases. We attempted to optimize the potency and selectivity of sulfircin for Cdc25A by modifying three structural areas of the molecule. An anionic group is required for potency and malonate was found to be an effective substitute for sulfate.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1997
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788897
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