Author/Authors :
Mar?lia O. F. Goulart، نويسنده , , Carlos L. Zani، نويسنده , , Josealdo Tonholo، نويسنده , , Luciano R. Freitas، نويسنده , , Fabiane C. de Abreu، نويسنده , , Ala?de B. Oliveira، نويسنده , , Délio S. Raslan، نويسنده , , Sérgia Starling، نويسنده , , Egler Chiari، نويسنده ,
Abstract :
With the aim of understanding the influence of redox potentials on the trypanocidal activity, a series of quinones were tested in vitro with trypomastigotes of Trypanosoma cruzi and their first cathodic potentials (Epcl) measured by cyclic voltammetry. All quinones with Epcl> −0.72V were active, while most of those with Epcl< −0.72V were inactive, suggesting a contribution of the easiness of reduction on the biological activity.
